ENERGY-DEPENDENT PROTEIN FOLDING: MODELING HOW A PROTEIN FOLDING MACHINE MAY WORK [VERSION 1; PEER REVIEW: 1 APPROVED, 2 APPROVED WITH RESERVATIONS]

Energy-dependent protein folding: modeling how a protein folding machine may work [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Proteins fold robustly and reproducibly in vivo, but many cannot fold in vitro in isolation from cellular components.Despite the remarkable progress that has been achieved by the artificial intelligence approaches in predicting the protein native conformations, the pathways that lead to such conformations, either in vitro or in vivo, re

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Water quality in three potential drought refuges in an arid-land river: assessing habitat suitability for at-risk fish species

Drought is a common disturbance in arid-land streams and rivers.The survival of aquatic species depends on access to refuge habitats where water quality remains high.Over the past century, modified flow regimes and altered watershed and instream characteristics have led to the extinction and endangerment of numerous fish species endemic to the sout

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Health Inequalities in Diabetes Mellitus and Hypertension: A Parish Level Study in the Northern Region of Portugal

Introduction: Diabetes and hypertension are highly prevalent conditions in Portugal.Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies.This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the p

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